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What is Proin? Proin is an aid in the management of urinary incontinence in dogs. Proin requires a prescription from your veterinarian. For: Dogs Benefits: • Is a supplement for urinary incontinence in dogs • Ensures sustained phenylpropanolamine levels in the blood stream and may help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability How it works: Proin contains the active ingredient phenylpropanolamine, an adrenergic agent that works by tightening the bladder sphincter muscle, which helps to control urine leakage. Cautions: Don’t give Proin with ephedrine or epinephrine, and don’t give it within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Possible side effects can occur, including restlessness, or loss of appetite, difficulty breathing, hives, and swelling of the lips, tongue, or face. If these or any other side effects occur, contact your veterinarian immediately. We do not ship Proin to Arkansas, Iowa and Oregon where it is classified as a controlled substance. More Information: Brand Name Proin (PRN Pharmacal) Generic Name Phenylpropanolamine What is the most important information I should know about Proin: Proin is a prescription medication FDA approved for veterinary use in dogs. Proin is available as 25mg, 50mg and 75mg chewable tablets. Proin may cause restlessness, irritability, or loss of appetite. What is Proin: Proin is an adrenergic agent used as a supplemental product for urinary incontinence in dogs. Proin may also be used for purposes other than those listed in this guide. What should I discuss with my veterinarian before giving Proin to my pet: Tell your veterinarian if your pet has ever had an allergic reaction to this medication. Tell your veterinarian if your pet has glaucoma, hyperthyroid disease, diabetes, heart problems or high blood pressure. Tell your veterinarian if your pet is pregnant or lactating. How should this medication be given: The usual dose for dogs is 0.4-0.8mg/pound every 12 hours. Give Proin exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Proin at room temperature away from moisture and heat. Keep this medication away from children and pets. What happens if I miss giving a dose: Give the missed dose as soon as you remember during the same day. However, if you don¿t remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication. What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of overdose may include increased blood pressure, increased heart rate, seizures or coma. What should I avoid while giving Proin to my pet: Do not give Proin with ephedrine or epinephrine and do not give within 2 weeks of using an MAOi such as selegilene or Preventic Collar. What are the possible side effects of Proin: Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome. What other drugs will affect Proin: Before giving Proin, tell your veterinarian if your pet is being given digoxin, NSAIDs such as aspirin or Rimadyl, tricyclic antidepressants such as clomipramine, and beta blockers such as atenolol, or any other prescription or over the counter medications. Where can I get more information: Your pharmacist has additional information about Proin written for health professionals that you may read. Directions: • Proin liver flavored chewable tablets are available by prescription for use in dogs to treat urinary incontinence. • Proin may cause restlessness, irritability, or loss of appetite. • Tell your veterinarian about any other medication you may be giving your pet. Tip: Give this medication exactly as directed by your veterinarian. Do not exceed 1.8mg/lb per day. The medication may be given with food. Storage: Should be stored at room temperature away from moisture and heat. Keep this medication away from children and pets.